2022 NFL schedule – Full list of opening betting odds for Week 1 games

The 2022 NFL schedule has finally arrived, and Caesars Sportsbook has released the latest point totals and spreads for all of the Week 1 games. Bettors will have plenty of time to make calls on which games from the Week 1 slate are the most intriguing.

The defending Super Bowl champion Los Angeles Rams welcome Josh Allen and the Buffalo Bills to SoFi Stadium to kick the season off on Sept. 8. And new Denver Broncos QB Russell Wilson returns to Seattle to face the Seahawks at Lumen Field.

Check out the latest NFL odds below.

All odds are courtesy of Caesars Sportsbook.

Week 1 Lines

Buffalo Bills at Los Angeles Rams
Thursday, 8:20 p.m. ET, SoFi Stadium, Inglewood, California

Line: Rams (-1)
Money line: Rams (-120), Bills (+100)
Over/Under: 52.5 points

San Francisco 49ers at Chicago Bears
Sunday, 1:05 p.m ET, Soldier Field, Chicago

Line: 49ers (-6)
Money line: 49ers (-270), Bears (+220)
Over/Under: 43 points

New England Patriots at Miami Dolphins
Sunday, 1:05 p.m ET, Hard Rock Stadium, Miami Gardens, Florida

Line: Dolphins (-3)
Money line: Dolphins (-150), Patriots (+130)
Over/Under: 44.5 points

New Orleans Saints at Atlanta Falcons
Sunday, 1:05 p.m ET, Mercedes-Benz Stadium, Atlanta

Line: Saints (-3)
Money line: Saints (-170), Falcons (+145)
Over/Under: 42.5 points

Baltimore Ravens at New York Jets
Sunday, 1:05 p.m ET, MetLife Stadium, East Rutherford, New Jersey

Line: Ravens (-4)
Money line: Ravens (-190), Jets (+160)
Over/Under: 45.5 points

Pittsburgh Steelers at Cincinnati Bengals
Sunday, 1:05 p.m ET, Paul Brown Stadium, Cincinnati

Line: Bengals (-6)
Money line: Bengals (-270), Steelers (+220)
Over/Under: 44 points

Cleveland Browns at Carolina Panthers
Sunday, 1:05 p.m ET, Bank of America Stadium, Charlotte, North Carolina

Line: Browns (-4.5)
Money line: Browns (-200), Panthers (+170)
Over/Under: 43.5 points

Philadelphia Eagles at Detroit Lions
Sunday, 1:05 p.m ET, Ford Field, Detroit

Line: Eagles (-3.5)
Money line: Eagles (-200), Lions (+170)
Over/Under: 47 points

Indianapolis Colts at Houston Texans
Sunday, 1:05 p.m ET, NRG Stadium, Houston

Line: Colts (-7.5)
Money line: Colts (-380), Texans (+300)
Over/Under: 45 points

Jacksonville Jaguars at Washington Commanders
Sunday, 1:05 p.m ET, FedEx Field, Landover, Maryland

Line: Commanders (-4.5)
Money line: Commanders (-210), Jaguars (-175)
Over/Under: 58.5 points

Kansas City Chiefs at Arizona Cardinals
Sunday, 4:25 p.m ET, State Farm Stadium, Glendale, Arizona

Line: Chiefs (-3)
Money line: Chiefs (-160), Cardinals (+140)
Over/Under: 55 points

Green Bay Packers at Minnesota Vikings
Sunday, 4:25 p.m ET, U.S. Bank Stadium, Minneapolis

Line: Packers (-1.5)
Money line: Packers (-125), Vikings (+105)
Over/Under: 48.0 points

Los Angeles Chargers at Las Vegas Raiders
Sunday, 4:25 p.m ET, Allegiant Stadium, Paradise, Nevada

Line: Chargers (-4)
Money line: Chargers (-190), Raiders (+160)
Over/Under: 51.5 points

New York Giants at Tennessee Titans
Sunday, 4:25 p.m ET, Nissan Stadium, Nashville, Tennessee

Line: Titans (-6.5)
Money line: Titans (-300), Giants (+240)
Over/Under: 44 points

Tampa Bay Buccaneers at Dallas Cowboys
Sunday, 8:30 p.m ET, At&T Stadium, Arlington, Texas

Line: Buccaneers (-2.5)
Money line: Buccaneers (-135), Cowboys (+115)
Over/Under: 52 points

Denver Broncos at Seattle Seahawks
Monday, 7:30 p.m ET, Lumen Field, Seattle

Line: Broncos (-3.5)
Money line: Broncos (-180), Seahawks (+155)
Over/Under: 41.5 points